It would only be about a 6 or 7 hour drive for me. I live way down in the western tip of the state. It is about 6 hours to Richmond, and about 3 hours to Roanoke. I am closer to Knoxville, TN than about any other "major" city..UNfortunate as it is..
I'm only about an hour from Kingsport, Bristol and Johnson City TN.